Jose Mourinho’s men reached the round of sixteen after emerging as second in Group G that was headed by Juventus.
In the other draws, Niko Kovac men Bayern Munich play Champions League finalists Liverpool with the first leg held at Anfield.
Manchester City was handed a smile after being drawn with Schalke and Tottenham will face Bundesliga leader Borussia Dortmund.
In Spain, Real Madrid was drawn with Dutch side Ajax while Barcelona play Lyon. Atletico Madrid battle it with Juventus
In Italy, Roma open up with FC Porto from Portugal
- Schalke v Manchester City
- Atletico Madrid v Juventus
- Manchester United v Paris St-Germain
- Tottenham v Borussia Dortmund
- Lyon v Barcelona
- Roma v Porto
- Ajax v Real Madrid
- Liverpoolv Bayern Munich