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Bale is set to be awarded before the Spanish game having surpassed Ian Rush’s 28-goal mark earlier this year.
Aaron Ramsey who registered his name of the score sheet as Arsenal beat Fulham 5-1 also missed training also missed training on Monday.
Leeds striker Tyler Roberts sat out the session following a heavy recent workload.
Wales face the Republic of Ireland at the Aviva Stadium in Dublin on October 16 2018 having triumphed over Northern Ireland in September.
Gareth Bale remains a doubt for Thursday’s high-profile friendly with Spain in Cardiff.
Swansea City defender Joe Rodon will have a chance to shine having received a shock call-up to the Wales squad.
Wales Called Up Squad.
Goalkeepers: Wayne Hennessey (Crystal Palace), Danny Ward (Leicester City), Adam Davies (Barnsley)
Defenders: Ashley Williams (Stoke City, James Chester (Aston Villa), Ben Davies (Tottenham Hotspur), Chris Gunter (Reading), Connor Roberts (Swansea City), Christopher Mepham (Brentford), Jazz Richards (Cardiff City), Ethan Ampadu (Chelsea), Paul Dummett (Newcastle United), Declan John (Swansea City)
Midfielders: Joe Allen (Stoke City), Aaron Ramsey (Arsenal), Andy King (Leicester City), David Brooks (Bournemouth), Matthew Smith (FC Twente)
Forwards: Gareth Bale (Real Madrid), Ben Woodburn (Sheffield United), Harry Wilson (Derby County), Tom Lawrence (Derby County), Sam Vokes (Burnley), George Thomas (Scunthorpe United), Tyler Roberts (Leeds United)
Goalkeepers: David De Gea (Manchester United), Kepa Arrizabalaga (Chelsea), Pau Lopez (Real Betis)
Defenders: Cesar Azpilicueta (Chelsea), Raul Albiol (Napoli), Nacho, Sergio Ramos (Real Madrid), Marcos Alonso (Chelsea), Gaya (Valencia), Marc Bartra (Real Betis), Jonny Otto (Wolverhampton)
Midfielders: Sergio Busquets (Barcelona), Rodrigo, Saul, Koke (Atletico Madrid), Thiago Alcantara (Bayern Munich), Dani Ceballos (Real Madrid)
Forwards: Marco Asensio (Real Madrid), Alvaro Morata (Chelsea), Suso (AC Milan), Rodrigo Moreno (Valencia), Iago Aspas (Celta Vigo), Paco Alcacer (Borussia Dortmund)